Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1

@article{Groot2007IndomethacinIA,
  title={Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1},
  author={Derk Jan A. de Groot and Margaretha van der Deen and Tina P Le and Anouk Regeling and Steven de Jong and Elisabeth G. E. de Vries},
  journal={British Journal of Cancer},
  year={2007},
  volume={97},
  pages={1077 - 1083}
}
Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC4-Adr was highly sensitive for indomethacin compared with the parental doxorubicin-sensitive line GLC4. The purpose of this study was to analyse the relationship between hypersensitivity to indomethacin… CONTINUE READING

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