Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.

@article{Basivireddy2003IndomethacininducedFR,
  title={Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.},
  author={Jayasree Basivireddy and Molly Jacob and Prabhu Ramamoorthy and Anna Benjamin Pulimood and K. V. Balasubramanian},
  journal={Biochemical pharmacology},
  year={2003},
  volume={65 4},
  pages={683-95}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause small intestinal damage but the pathogenesis of this toxicity is not well established. Our earlier work has shown that villus enterocytes are most susceptible to the effects of indomethacin, a commonly used NSAID. This study looked at the acute effect of indomethacin on brush border membranes (BBM), which… CONTINUE READING