Indomethacin and cyclosporin together produce marked renal vasoconstriction in humans.

@article{Sturrock1994IndomethacinAC,
  title={Indomethacin and cyclosporin together produce marked renal vasoconstriction in humans.},
  author={N D Sturrock and Chim C Lang and Allan D. Struthers},
  journal={Journal of hypertension},
  year={1994},
  volume={12 8},
  pages={919-24}
}
OBJECTIVE To test the hypothesis that an imbalance in intrarenal prostaglandins plays a role in cyclosporin-induced nephrotoxicity. METHODS AND RESULTS Indomethacin was given in combination with cyclosporin to healthy volunteers. Cyclosporin alone (10 mg/kg twice a day) for 4 days had no effect on effective renal plasma flow (ERPF) and glomerular filtration rate but 4 days of therapy with cyclosporin (10 mg/kg twice a day) and indomethacin (50 mg twice a day) in combination resulted in a 37… CONTINUE READING
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