Indomethacin Inhibits Lordosis Induced by Ring A-Reduced Progestins: Possible Role of 3α-Oxoreduction in Progestin-Facilitated Lordosis

@article{Beyer1999IndomethacinIL,
  title={Indomethacin Inhibits Lordosis Induced by Ring A-Reduced Progestins: Possible Role of 3$\alpha$-Oxoreduction in Progestin-Facilitated Lordosis},
  author={Carlos Beyer and Oscar Gonz{\'a}lez‐Flores and Juan Manuel Ram{\'i}rez-Ordu{\~n}a and Gabriela Gonz{\'a}lez-Mariscal},
  journal={Hormones and Behavior},
  year={1999},
  volume={35},
  pages={1-8}
}
Progestins with a delta-4-3-keto configuration bind to the progestin receptor (PR) and facilitate estrous behavior in estrogen-primed rats. Some ring A-reduced progestins [5alpha-dihydroprogesterone (alphaDHP), allopregnanolone, and epipregnanolone] are more potent estrus-inducing agents than progesterone when iv injected despite their lower affinity for the PR. Yet the estrus-inducing action of such progestins is reduced by the antiprogestin RU486, suggesting that binding to the PR is required… Expand
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TLDR
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