Indomethacin, a cox inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.

@article{Frenkian2001IndomethacinAC,
  title={Indomethacin, a cox inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.},
  author={M{\'e}lin{\'e}e Frenkian and Nadine Segond and Elisabeth Pidoux and R{\'e}gis Cohen and Annick Jullienne},
  journal={Prostaglandins & other lipid mediators},
  year={2001},
  volume={65 1},
  pages={11-20}
}
High levels of prostaglandins (PGs) are currently found in tumoral cells, due to expression of the inducible PGs synthesis enzyme, the cyclooxygenase 2 (COX 2). Non Steroidal Anti Inflammatory Drugs (NSAIDs) possess an antitumoral effect related, in a large extend, to the inhibition of this enzyme. It was recently suggested that the decreased activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme catabolysing PGs, may be responsible too for experimentally induced colon… CONTINUE READING
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