Indolo[3,2-b]quinolines: synthesis, biological evaluation and structure activity-relationships.

  title={Indolo[3,2-b]quinolines: synthesis, biological evaluation and structure activity-relationships.},
  author={Eyunni V K Suresh Kumar and Jagan Reddy Etukala and Seth Y Ablordeppey},
  journal={Mini reviews in medicinal chemistry},
  volume={8 6},
The tetracyclic indolo[3,2-b]quinoline ring system constitutes an important structural moiety in natural products exhibiting numerous biological activities. In particular, indolo [3, 2-b]quinoline, commonly known as linear quindoline is of particular interest, because of its rigid structure and scope of derivatization. Although the core linear quindoline skeleton shows little or no activity in several biological systems, introduction of a methyl group on the N-5 atom leading to cryptolepine… CONTINUE READING


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