Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis.

  title={Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis.},
  author={Maria P{\'e}rez and Margarida Espadinha and Maria M. M. Santos},
  journal={Current pharmaceutical design},
  volume={21 38},
Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia and in the life science industries due to their broad bioactivity profile. In particular, the main biological effects described for indoloquinolizidines include analgesic, anti-inflammatory, antihypertensive, and antiarrhythmic activities, as well as inhibition of multiple ion channels, affinity for opioid receptors, and activity against Leishmania. For that reason, in the last… 
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