Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase.

@article{Werner1976IndolmycinIP,
  title={Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase.},
  author={Rolf G{\"u}nter Werner and L F Thorpe and W O Reuter and Knud H. Nierhaus},
  journal={European journal of biochemistry},
  year={1976},
  volume={68 1},
  pages={1-3}
}
Indolmycin specifically prevents the formation of tryptophanyl-tRNA in a prokaryotic system in vitro using Escherichia coli enzymes. However, the drug has little effect in an eukaryotic system in vitro (rat liver enzymes). Analysis of the type of inhibition revealed that indolmycin competes with tryptophan as a pure competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase. 

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase.

The Journal of antimicrobial chemotherapy • 2007
View 8 Excerpts
Highly Influenced

Non-coding RNAs as antibiotic targets.

Biochemical pharmacology • 2017
View 2 Excerpts

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.

Proceedings of the National Academy of Sciences of the United States of America • 2015
View 3 Excerpts

Similar Papers

Loading similar papers…