Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.

@article{Krystal2001IndolinoneTK,
  title={Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.},
  author={Geoffrey W. Krystal and Sittisak Honsawek and David Kiewlich and Congxin Liang and Stefan Vasile and L. Sun and Gerald McMahon and Kenneth E Lipson},
  journal={Cancer research},
  year={2001},
  volume={61 9},
  pages={3660-8}
}
Six indolinone tyrosine kinase inhibitors were characterized for their ability to inhibit Kit kinase and for their effects on the growth of small cell lung cancer (SCLC) cell lines. All of the six compounds were potent inhibitors of Kit kinase in a biochemical assay. A homology model of compound binding to the ATP binding site could account for the increased potency observed with the addition of a propionate moiety to the indolinone core but not the increase observed with addition of a chloride… CONTINUE READING
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