Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

@article{Matnani2017IndolentTA,
  title={Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update},
  author={Rahul G. Matnani and Karthik A. Ganapathi and Suzanne K. Lewis and Peter H. R. Green and Bachir Alobeid and G. Bhagat},
  journal={Hematological Oncology},
  year={2017},
  volume={35},
  pages={16 - 3}
}
Primary gastrointestinal (GI) T‐ and NK‐cell lymphomas are usually aggressive neoplasms associated with high morbidity and mortality. Over the past two decades, however, cases of primary GI lymphoproliferative disorders (LPDs) or lymphomas of T‐ or NK‐cell derivation with indolent behavior have been reported. These LPDs are rare and they can be challenging to diagnose as they share clinical and pathological features with both, inflammatory disorders and aggressive T‐ and NK‐cell lymphomas… 
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TLDR
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TLDR
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TLDR
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TLDR
Targeted next-generation sequencing and comprehensive immunophenotypic analysis of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract provides insights into the pathogenetic bases of these diseases and confirms the heterogeneous nature ofThese diseases.
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TLDR
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TLDR
Feline LGITL is a relevant model for human T-cell lymphoproliferative disorder of the gastrointestinal tract, a rare and poorly described entity, and is proposed as a new model of digestive T- cell lymphomagenesis.
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TLDR
An unusual case of an indolent CD8+ T-cell lymphoproliferative disorder in the gastrointestinal tract accompanied by neck lymph node infiltration and new onset of classic Hodgkin's lymphoma after two years follow-up is described.
An unusual case report of indolent T-cell lymphoproliferative disorder with aberrant CD20 expression involving the gastrointestinal tract and bone marrow
TLDR
Recognition of this unusual immunophenotype of indolent T-cell LPD of GI helps to eschew misdiagnosis of B-cell and other high grade lymphomas and inappropriate aggressive treatment.
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