Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

  title={Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update},
  author={Rahul G. Matnani and Karthik A. Ganapathi and Suzanne K. Lewis and Peter H. R. Green and Bachir Alobeid and G. Bhagat},
  journal={Hematological Oncology},
  pages={16 - 3}
Primary gastrointestinal (GI) T‐ and NK‐cell lymphomas are usually aggressive neoplasms associated with high morbidity and mortality. Over the past two decades, however, cases of primary GI lymphoproliferative disorders (LPDs) or lymphomas of T‐ or NK‐cell derivation with indolent behavior have been reported. These LPDs are rare and they can be challenging to diagnose as they share clinical and pathological features with both, inflammatory disorders and aggressive T‐ and NK‐cell lymphomas… 
Gastrointestinal T- and NK-cell lymphomas and indolent lymphoproliferative disorders.
The salient clinical, histopathologic, immunophenotypic, and molecular characteristics of primary GI T/NK-cell lymphomas and LPDs are described in view of recent developments and the differential diagnostic considerations are discussed.
Diagnostic approach to T- and NK-cell lymphoproliferative disorders in the gastrointestinal tract.
In Asia and South America, it is not uncommon to see involvement of the gastrointestinal tract by EBV-associated extranodal NK/T cell lymphoma, nasal type, which must be distinguished from NK cell enteropathy and EBv-associated mucocutaneous ulcers.
Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review
A biomarker-based approach to the diagnosis is provided and the most common issues in differentiating iTLPD-GI from other neoplastic and non-neoplastic disorders are described.
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case
Indolent T-cell lymphoproliferative disorder is usually a disease of adulthood and affected the stomach, sparing small intestine and colon, and the small bowel and colon are the sites most commonly involved.
Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract
Targeted next-generation sequencing and comprehensive immunophenotypic analysis of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract provides insights into the pathogenetic bases of these diseases and confirms the heterogeneous nature ofThese diseases.
Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders
The current state of knowledge about the main types of immune cells in the gastrointestinal mucosa and the processes by which they may transform into neoplasms are summarized.
Feline low-grade intestinal T cell lymphoma: a unique natural model of human indolent T cell lymphoproliferative disorder of the gastrointestinal tract
Feline LGITL is a relevant model for human T-cell lymphoproliferative disorder of the gastrointestinal tract, a rare and poorly described entity, and is proposed as a new model of digestive T- cell lymphomagenesis.
Indolent T cell lymphoproliferative disorder of the gastrointestinal tract: an uncommon case with lymph node involvement and the classic Hodgkin's lymphoma.
An unusual case of an indolent CD8+ T-cell lymphoproliferative disorder in the gastrointestinal tract accompanied by neck lymph node infiltration and new onset of classic Hodgkin's lymphoma after two years follow-up is described.
An unusual case report of indolent T-cell lymphoproliferative disorder with aberrant CD20 expression involving the gastrointestinal tract and bone marrow
Recognition of this unusual immunophenotype of indolent T-cell LPD of GI helps to eschew misdiagnosis of B-cell and other high grade lymphomas and inappropriate aggressive treatment.


Benign Indolent CD56-Positive NK-Cell Lymphoproliferative Lesion Involving Gastrointestinal Tract in an Adolescent
The first Korean case, as well as the first case in an adolescent, of NK-cell enteropathy is reported, and early recognition of this entity could be important for appropriate disease management.
CD4‐positive small T‐cell lymphoma of the intestine presenting with severe bile‐acid malabsorption: a supportive symptom control approach
Twenty cases of a distinct ITCL associated with sprue-like symptoms have been reported, showing a lymphomatous infiltrate of small, mildly atypical CD4/CD8 lymphoid cells occupying the lamina propria, rarely infiltrating the epithelium and having a strikingly benign clinical course.
CASE REPORT: CD4+ T-Cell Lymphoproliferative Disorder of the Gut Clinically Mimicking Celiac Sprue
Primary gastrointestinal T-cell lymphoproliferative disorders are less common than those of B cell origin and, at present, are not well characterized. There appears to be a spectrum of behavior from
Indolent Small Intestinal CD4+ T-cell Lymphoma Is a Distinct Entity with Unique Biologic and Clinical Features
Unique pathobiologic features warrant designation of indolent small intestinal CD4+ T-cell lymphoma as a distinct entity, greater awareness of which would avoid misdiagnosis as EATL or an inflammatory disorder, especially celiac disease.
Small intestinal CD4+ T-cell lymphoma: a rare distinctive clinicopathological entity associated with prolonged survival
The opportunity to diagnose an additional case of this T-cell low grade lymphoma in a patient without any evidence of celiac disease, associated with prolonged survival, was offered.
Indolent peripheral T-cell lymphoma involving the gastrointestinal tract.
A case of lymphomatoid gastropathy: a self-limited pseudomalignant natural killer (NK)-cell proliferative disease mimicking NK/T-cell lymphomas
A rare case of lymphomatoid gastropathy in a 71-year-old female is reported, it is important that endoscopists consider this rare entity in the differential diagnosis, and excessive treatment should be avoided.
Indolent CD8-positive Lymphoid Proliferation of the Ear: A Distinct Primary Cutaneous T-cell Lymphoma?
These cases do not correspond to a recognized cutaneous T-cell lymphoma as described in the recent WHO/EORTC classification, but the apparent striking propensity for the ear suggests that they might represent a specific entity.