Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey

@article{Schindler2015IndoleamineHI,
  title={Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey},
  author={Emmanuelle Andree Danielle Schindler and Christopher H Gottschalk and Marsha J Weil and Robert E. Shapiro and Douglas A Wright and Richard Andrew Sewell},
  journal={Journal of Psychoactive Drugs},
  year={2015},
  volume={47},
  pages={372 - 381}
}
Cluster headache is one of the most debilitating pain syndromes. [] Key Method Participants were recruited from cluster headache websites and headache clinics. The final analysis included responses from 496 participants. The survey was modeled after previously published surveys and was available online. Most responses were chosen from a list, though others were free-texted. Conventional abortive and preventative medications were identified and their efficacies agreed with those previously published. Theā€¦
View on Taylor & Francis
ouramazingworld.org
50 Citations
Highly Influential Citations
3
Background Citations
18
Methods Citations
1
Results Citations
2

50 Citations

Are psychedelics the answer to chronic pain: a review of current literature.

It is important that further research is conducted on the efficacy of psychedelics in chronic pain conditions, given the current epidemic use of opioids, and that patients are in desperate need of an alternative treatment.

Drug Treatment of Cluster Headache

This review summarizes drug therapy of cluster attacks and prophylactic treatment and the efficacy of monoclonal antibodies to the calcitonin gene-related peptide so far has been only demonstrated for episodic cluster headache.

Drug profile: galcanezumab for prevention of cluster headache

The negative trial results of galcanezumab for chronic cluster headache may be due to the refractory nature and sheds light on the critical need to investigate the underlying biology and therapeutic options.

Peptides, MAbs, Molecules, Mechanisms, and More: Taking a Stab at Cluster Headache.

  • S. Joshi
  • Medicine, Psychology
    Headache
  • 2020
Recent therapeutic advances in the treatment of cluster headache such as monoclonal antibodies as well as non-invasive vagus nerve stimulation are highlighted, and future potential therapeutic targets are examined.

Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

Changes in hypothalamic-diencephalic FC correlated negatively with relative reduction in attack frequency, implicating this neural pathway in treatment response, and further clinical studies are warranted.

Psychedelics as preventive treatment in headache and chronic pain disorders

Clinical applications of hallucinogens: A review.

This review will present data on several classes of hallucinogens with a particular focus on psychedelics, entactogens, and dissociatives, for which clinical utility has been most extensively documented, with important ramifications for their potential therapeutic value.

Recent advances in the diagnosis and management of cluster headache

Clinical, pathophysiologic, and therapeutic features of cluster headache are reviewed, which include new treatments for episodic cluster headache (galcanezumab and non-invasive vagus nerve stimulation) and recent updates in diagnosis include the redefinition of chronic cluster headache.

Modern Clinical Research on LSD

  • M. Liechti
  • Psychology, Medicine
    Neuropsychopharmacology
  • 2017
All modern clinical studies using the classic hallucinogen lysergic acid diethylamide in healthy subjects or patients in the last 25 years are reviewed herein and should contribute to further investigations of the therapeutic potential of LSD in psychiatry.

Serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: A systematic review

References

SHOWING 1-10 OF 54 REFERENCES

The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: An open, non-randomized case series

This study investigates the efficacy of a nonhallucinogenic analog of LSD, BOL-148, which has been studied in volunteers and in patients suffering from vascular headaches but not, apparently, in patients with CH.

Treatment of acute cluster headache with sumatriptan. The Sumatriptan Cluster Headache Study Group.

  • Medicine
    The New England journal of medicine
  • 1991
Sumatriptan is an effective and well-tolerated treatment for acute attacks of cluster headache and was well tolerated in patients with cluster headache.

Oral zolmitriptan is effective in the acute treatment of cluster headache

To the Editor: I read with interest the trial by Bahra et al.1 on the treatment of acute cluster headache with oral zolmitriptan, in which they found a modest but significant difference between theā€¦

Serotonergic hallucinogens and emerging targets for addiction pharmacotherapies.

  • S. Ross
  • Psychology, Medicine
    The Psychiatric clinics of North America
  • 2012

Cluster headache: pathogenesis, diagnosis, and management

Treatment of acute cluster headache with 20 mg sumatriptan nasal spray ā€“ an open pilot study

It is concluded that 20 mg sumatriptan nasal spray might be an alternative therapy for the treatment of cluster headache attacks, but double-blind studies are needed to further evaluate its efficacy.

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder.

In a controlled clinical environment, psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.

Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action.

It is concluded that hypothalamic stimulation has remarkable efficacy in most, but not all, patients with treatment-resistant chronic cluster headache, and is not due to a simple analgesic effect or to hormonal changes.

Hallucinogens and dissociative agents naturally growing in the United States.

Response of cluster headache to psilocybin and LSD

The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition to find out whether these patients had aborted attacks or reported remission period extension.
...