[Indoleamine 2,3-Dioxygenase Activity in Intracystic Breast Tumors].


We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)in intra-cystic tumors of the breast. IDO activitycan be measured byusing the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn were measured by high performance liquid chromatography(HPLC). We took liquid from 3 intra-cystic papilloma cases and 5 intra-cystic breast cancer cases. Then, we measured the Trp/Kyn ratio in these samples, and we evaluated the difference in the Trp/Kyn ratio between the papilloma group and the breast cancer group. The Trp/Kyn ratio was significantly lower in the breast cancer group than in the papilloma group. These results suggest that measuring the Trp/Kyn ratio in cystic liquid from intra-cystic breast lesions is useful to distinguish benign intra-cystic lesions from malignant intra-cystic lesions.

Cite this paper

@article{Sakurai2016Indoleamine2A, title={[Indoleamine 2,3-Dioxygenase Activity in Intracystic Breast Tumors].}, author={Kenichi Sakurai and Shigeru Fujisaki and Keita Adachi and Shuhei Suzuki and Yuki Masuo and Saki Nagashima and Yukiko Hara and Katsuhisa Enomoto and Tomohiro Hirano and Ryouichi Tomita and Kenji Gonda}, journal={Gan to kagaku ryoho. Cancer & chemotherapy}, year={2016}, volume={43 10}, pages={1295-1297} }