Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis.

@article{Criado2009Indoleamine2D,
  title={Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis.},
  author={Gabriel Criado and Egle {\vS}imelyte and Julia J. Inglis and David Essex and Richard O Williams},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 5},
  pages={
          1342-51
        }
}
OBJECTIVE Indoleamine 2,3 dioxygenase (IDO) is a catabolic enzyme that initiates the kynurenine pathway of tryptophan degradation and has immunomodulatory properties. The aim of this study was to investigate the regulation of collagen-induced arthritis by tryptophan catabolism mediated by IDO. METHODS Arthritis was induced by immunization with type II collagen. After induction of arthritis, the expression of IDO was analyzed by quantitative reverse transcription-polymerase chain reaction. The… CONTINUE READING

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