Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.

@article{Bubnoff2011Indoleamine2M,
  title={Indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells and macrophages in infectious and noninfectious cutaneous granulomas.},
  author={Dagmar von Bubnoff and Marina Scheler and Helene Wilms and J Wenzel and Nikolas von Bubnoff and Georg H{\"a}cker and Joachim L Schultze and Alexey Popov and Paul Racz and Thomas Bieber and Claudia Wickenhauser},
  journal={Journal of the American Academy of Dermatology},
  year={2011},
  volume={65 4},
  pages={
          819-832
        }
}
BACKGROUND The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan, and this degradation is an immunosuppressive mechanism that is mainly used by antigen-presenting cells. IDO-expressing dendritic cells and macrophages have previously been identified as components of lymph node granulomas after Listeria monocytogenes infection. In this study we undertook an analysis of IDO expression in granulomas of infectious and noninfectious origin in the human skin… CONTINUE READING

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