Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells.

@article{Curti2010Indoleamine2L,
  title={Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells.},
  author={Antonio Curti and Sara Trabanelli and Chiara Onofri and Michela Aluigi and Valentina Salvestrini and Darina O{\vc}adl{\'i}kov{\'a} and Cecilia Evangelisti and Sergio Rutella and Raimondo de Cristofaro and Emanuela Ottaviani and Michele Baccarani and Roberto Massimo Lemoli},
  journal={Haematologica},
  year={2010},
  volume={95 12},
  pages={2022-30}
}
BACKGROUND The immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients with acute myeloid leukemia, resulting in the inhibition of T-cell proliferation and the induction of regulatory T cells. Acute myeloid leukemia cells can be differentiated into dendritic cells, which have increased immunogenicity and have been proposed as vaccines against leukemia. DESIGN AND METHODS Leukemic… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
31 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…