Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation.

@article{Miyazaki2009Indoleamine2A,
  title={Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation.},
  author={Takeshi Miyazaki and Kouzo Moritake and Kiyofumi Yamada and Nobumasa Hara and Harumi Osago and Tomoko Shibata and Yasuhiko Akiyama and Mikako Tsuchiya},
  journal={Journal of neurosurgery},
  year={2009},
  volume={111 2},
  pages={230-7}
}
OBJECT Indoleamine 2,3-dioxygenase (IDO), a kynurenine pathway (KP) enzyme catalyzing oxidation of the essential amino acid tryptophan (Trp), is thought to be involved in the immune resistance of malignant tumors through T-cell inactivation caused by Trp depletion and metabolite accumulation. Human malignant gliomas may use this strategy to escape immune attack. The object of this study was to investigate the possibility of IDO-dependent Trp depletion by malignant gliomas and the practicability… CONTINUE READING