Indoleamine 2,3 dioxygenase and regulation of T cell immunity.

  title={Indoleamine 2,3 dioxygenase and regulation of T cell immunity.},
  author={Andrew L Mellor},
  journal={Biochemical and biophysical research communications},
  volume={338 1},
Regulation of adaptive immune responses is critically important to allow the adaptive immune system to eradicate infections while causing minimal collateral damage to infected tissues, as well as preventing autoimmune disease mediated by self-reactive lymphocytes. Tumors and pathogens that cause persistent infections can subvert immunoregulatory processes to protect themselves from destruction by T cells, to the detriment of patients. A growing body of evidence supports the hypothesis that… CONTINUE READING
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