Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease

@article{Swardfager2009Indoleamine2A,
  title={Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease},
  author={Walter Swardfager and Nathan Herrmann and Yekta Dowlati and Paul Oh and Krista L. Lanct{\^o}t},
  journal={Psychoneuroendocrinology},
  year={2009},
  volume={34},
  pages={1560-1566}
}
An increase in immune-stimulated synthesis of kynurenine from tryptophan by indoleamine 2,3-dioxygenase (IDO) has been observed in patients with coronary artery disease (CAD). However, neuropsychiatric correlates of IDO activation remain unexplored. We hypothesize that IDO activation, as measured by the kynurenine to tryptophan (K/T) ratio, is associated with depressive symptoms in those with CAD. This cross-sectional study recruited subjects with CAD (n=95) from a cardiac rehabilitation… CONTINUE READING
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