Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease

@article{Swardfager2009Indoleamine2A,
  title={Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease},
  author={Walter Swardfager and Nathan Herrmann and Yekta Dowlati and Paul I Oh and Alex Kiss and Scott E. Walker and Krista L. Lanct{\^o}t},
  journal={Psychoneuroendocrinology},
  year={2009},
  volume={34},
  pages={1560-1566}
}
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48 Citations
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48 Citations

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The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment
TLDR
Data suggest an inflammatory response characterized by IDO activation may be relevant to the development of PSCI, and the K/T ratio may be a clinically important biomarker.
Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: evidence from the Young Finns study.
Serum indoleamine 2,3-dioxygenase and kynurenine aminotransferase enzyme activity in patients with ischemic stroke
Neuropathology of Post-stroke Depression: Possible Role of Inflammatory Molecules and Indoleamine 2,3-dioxygenase
TLDR
Higher mean KYN/TRP ratios were demonstrated in stroke patients with depressive symptoms, suggesting that both mechanisms may play an etiological role in PSD.
Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
Kynurenine and depressive symptoms in a poststroke population
TLDR
Peripheral kynurenine/tryptophan ratios were not associated with depressive symptoms in a poststroke population, however, in exploratory analyses a proinflammatory bias was identified specifically in patients with mild depressive symptoms and associated with poststroke fatigue, suggesting an avenue for future research.
The immunometabolic role of indoleamine 2 3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall.
TLDR
Evidence from basic and clinical research showing that IDO is a major regulatory enzyme involved in the maintenance of immunohomeostasis in the vascular wall is summarized, as well as current knowledge about promising targets for the development of new anti-atherosclerotic drugs.
The Relationship Between Markers of Oxidative Stress and Depressive Symptoms in Coronary Artery Disease Patients
TLDR
Low concentrations of 8-ISO, a late-stage marker of oxidative damage to lipids, predicted greater depressive symptom severity measured by the Center for Epidemiological Studies Depression Scale, and lipid peroxidation may be an important correlate of depressive symptoms in CAD and should be further explored.
The role of tryptophan degradation in the association between inflammatory markers and depressive symptoms in chronic dialysis patients
  • G. Haverkamp, W. L. Loosman, C. Siegert
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2017
TLDR
The association between inflammatory markers and depressive symptoms in chronic dialysis patients was not mediated by TRP degradation along the kynurenine (KYN) pathway.
Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies.
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