Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

@inproceedings{Choe2013Indoleamine2,
  title={Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study},
  author={Ji-Young Choe and Ji Yun Yun and Yoon Kyoung Jeon and Se Hoon Kim and Gyeong-sin Park and Joo Ryoung Huh and Sohee Oh and Ji Eun Kim},
  booktitle={BMC Cancer},
  year={2013}
}
Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL. A total of 121 cases of HL were enrolled to do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers of positive cells using automated image… CONTINUE READING
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