Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells.

@article{Donovan2012Indoleamine2,
  title={Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells.},
  author={Michael J. Donovan and Vinita Tripathi and Michelle A. Favila and Nicholas S. Geraci and Michaela C. Lange and Wibke Ballhorn and Mary McDowell},
  journal={Parasite immunology},
  year={2012},
  volume={34 10},
  pages={464-72}
}
Dendritic cells (DC) play a pivotal role in regulating immunity, establishing immunologically privileged tissue microenvironments and maintaining homoeostasis. It is becoming increasingly clear that one key mechanism that mediates many DC functions is production of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO). For pathogens that cause chronic infection, exploitation of host DCs is a solution to establish and persist within a host. Leishmania parasites cause a range of clinical… CONTINUE READING
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