Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction.

  title={Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction.},
  author={Stephanie W Watts and Samantha K Shaw and Robert R Burnett and Anne M Dorrance},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={301 4},
Indoleamine 2,3-dioxygenase (IDO) metabolizes L-tryptophan to L-kynurenine, promotes immunosuppression, and has been described as a consumer of superoxide. We discovered IDO expression in periaortic fat and tested the hypothesis that periarterial IDO functionally reduces agonist-induced contraction. Our model was the thoracic aorta, abdominal aorta, and superior mesenteric artery of the male Sprague-Dawley rat. Periaortic fat from the thoracic aorta stained intensely for IDO, the brown fat… CONTINUE READING


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