Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex ζ‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.

@article{Eleftheriadis2016Indoleamine2D,
  title={Indoleamine 2,3‑dioxygenase downregulates T‑cell receptor complex $\zeta$‑chain and c‑Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T‑cells.},
  author={Theodoros Eleftheriadis and Georgios Pissas and Georgia Antoniadi and Konstantina Tsogka and Maria Sounidaki and Vassilios Liakopoulos and Ioannis Stefanidis},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 1},
  pages={
          925-32
        }
}
Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of these alterations, are partially mediated through IDO‑induced p53 upregulation. In two‑way mixed lymphocyte reactions (MLRs), IDO reduced cellular proliferation. In MLR‑derived T… Expand
Indoleamine 2, 3-dioxygenase Up-regulates Hypoxia-inducible Factor-1α Expression by Degrading L-tryptophan but Not Its Activity in Human Alloreactive T-cells.
TLDR
In human alloreactive T-cells, IDO up-regulates Hif-1α, by inducing p53 overexpression, however, HIF-1 α remains transcriptionally inactive. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.
TLDR
In alloreactive T cells, IDO increases p53 levels, and both IDO and p53 inhibit cell proliferation, glucose consumption and glycolysis, while lactate production and glutaminolysis are also suppressed by IDO, but not by p53. Expand
Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.
TLDR
In alloreactive T-cells, IDO through activation of the GCN2 kinase, decreases glucose influx and alters key enzymes involved in metabolism, decreasing aerobic glycolysis and glutaminolysis, acting in such a way that IDO could be considered as a constraining factor for allore active T-cell proliferation and differentiation to effector T- cell subtypes. Expand
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Considering that cell metabolism plays a significant role in lymphocyte differentiation and function, IDO may exert its immunomodulatory effect by interfering with cell metabolism. Expand
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TLDR
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Indolamine 2,3‐dioxygenase is expressed in the CNS and down‐regulates autoimmune inflammation
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