Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death

@inproceedings{Wang2015IndoleDF,
  title={Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death},
  author={Fu-qian Wang and Qing-yi Tong and Hao-ran Ma and Hong-feng Xu and Song Bo Hu and W. T. Ma and Yong-bo Xue and Jun-jun Liu and Jianping Wang and Hong-ping Song and Jin-wen Zhang and Geng Zhang and Yonghui Zhang},
  booktitle={Scientific reports},
  year={2015}
}
Diketopiperazines are important secondary metabolites of the fungi with variety bioactivities. Several species belonging to genus Chaetomium produce compounds of this class, such as chetomin. To identify new antitumor agents, secondary metabolites of fungus Chaetomium sp 88194 were investigated and three new indole diketopiperazines, Chaetocochins G (1), Oidioperazines E (2) and Chetoseminudin E (3), along with two known compounds Chetoseminudins C (4) and N-acetyl-β-oxotryptamine (5), were… CONTINUE READING