Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge.

  title={Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge.},
  author={Olga F. Smetanina and Anatoly I. Kalinovsky and Yu. V. Khudyakova and Mikhail V Pivkin and Pavel S Dmitrenok and Sergey N. Fedorov and Honglou Ji and Jong-Young Kwak and T A Kuznetsova},
  journal={Journal of natural products},
  volume={70 6},
Three new indole alkaloids, shearinines D, E, and F (1-3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1-4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce apoptosis in human leukemia HL-60 cells, and shearinine E also inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar. 
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