Corpus ID: 15280103

Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.

@article{Cover1999Indole3carbinolAT,
  title={Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.},
  author={C. Cover and S. Hsieh and E. Cram and C. Hong and J. Riby and L. Bjeldanes and G. Firestone},
  journal={Cancer research},
  year={1999},
  volume={59 6},
  pages={
          1244-51
        }
}
The current options for treating breast cancer are limited to excision surgery, general chemotherapy, radiation therapy, and, in a minority of breast cancers that rely on estrogen for their growth, antiestrogen therapy. The naturally occurring chemical indole-3-carbinol (I3C), found in vegetables of the Brassica genus, is a promising anticancer agent that we have shown previously to induce a G1 cell cycle arrest of human breast cancer cell lines, independent of estrogen receptor signaling… Expand
Indole-3-carbinol as a chemopreventive and anti-cancer agent.
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes
Steroid hormone mimics: molecular mechanisms of cell growth and apoptosis in normal and malignant mammary epithelial cells
  • K. Rahman, F. Sarkar
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2002
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