Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.

@article{Lee2005Indole3carbinolA3,
  title={Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner.},
  author={Seong-Ho Lee and Jong-Sik Kim and Kiyoshi Yamaguchi and Thomas E. Eling and Seung Joon Baek},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={328 1},
  pages={63-9}
}
Indole-3-carbinol (I3C), present in cruciferous vegetables, and its major in vivo product 3,3'-diindolylmethane (DIM), have been reported to suppress cancer development. However, the responsible molecular mechanisms are not fully understood. Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) is a TGF-beta superfamily gene associated with pro-apoptotic and anti-tumorigenic activities. The present study was performed to investigate whether I3C and DIM influence NAG-1 expression and to… CONTINUE READING