Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells.

@article{Rahman2003Indole3carbinolI,
  title={Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells.},
  author={K. M. Wahidur Rahman and Olivia Aranha and Fazlul H. Sarkar},
  journal={Nutrition and cancer},
  year={2003},
  volume={45 1},
  pages={101-12}
}
Recent results from epidemiology, in vitro cell culture and in vivo (animal and human) studies have suggested the benefits of indole-3-carbinol (I3C) for the prevention of many types of cancer, including breast cancer. However, there are no reports, to the best of our knowledge, on the effect of I3C on isogenic nontumorigenic and tumorigenic breast epithelial cells, and there is a significant void in our understanding of the molecular mechanism(s) by which I3C induces apoptotic cell death in… CONTINUE READING