Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.

@article{Armer2005Indole3aceticAA,
  title={Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.},
  author={Richard E Armer and Mark R Ashton and Edward A Boyd and Chris J Brennan and Frederick A Brookfield and Lucien Gazi and Sh{\^a}n L. Gyles and Philip A Hay and Michael G. Hunter and David Middlemiss and Mark T. Whittaker and Luzheng Xue and Roy Pettipher},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 20},
  pages={6174-7}
}
Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic… CONTINUE READING
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