Indole(ethyl)amine N-Methyltransferase in the Brain

@article{Morgan1969IndoleethylamineNI,
  title={Indole(ethyl)amine N-Methyltransferase in the Brain},
  author={Merrily Morgan and Arnold J. Mandell},
  journal={Science},
  year={1969},
  volume={165},
  pages={492 - 493}
}
An enzyme which N-methylates various indole(ethyl)amine substrates was isolated from brain, separated from the pituitary and the pineal glands. It appeared localized in the supernatant and synaptosomal areas after discontinuous sucrose-gradient ultracentrifugation. This is the first demonstration of the enzyme in brain. 

Methyltetrahydrofolic Acid Mediates N- and O-Methylation of Biogenic Amines

With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.

Substrate specificity and heterogeneity of N-methyltransferases.

  • A. Thithapandha
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1972

Indole(ethyl)amine N-methyltransferase in human brain.

Preliminary evidence gathered in laboratories from rats infused intraventricularly with bufotenin has suggested that this substance is at least as potent as its powerfully hallucinogenic 5-methoxy congener, and may not easily cross the blood-brain barrier.

Inhibition of indolethylamine-N-methyltransferase by S-adenosylhomocysteine.

ENZYMATIC N‐METHYLATION OF INDOLEAMINES BY MAMMALIAN BRAIN: FACT OR ARTEFACT?

Examination of the reaction products by means of exhaustive thin‐layer chromatographic analysis failed to reveal evidence of significant N‐ methylation of tryptamine or N‐methyltryptamine by S‐adenosylmethionine, but N‐methylation of indoleamine was reproducibly demonstrable.

THE DISTRIBUTION AND PROPERTIES OF THE NONSPECIFIC N‐METHYLTRANSFERASE IN BRAIN

Enzymatic activity is unevenly distributed in the brain with the highest activity in the cerebral cortex and striaturn of the rat and in the subcortical white matter in man.

Indolethylamine-N-methyltransferase in developing rabbit lung.

The activity of indolethylamine-N-methyltransferase (INMT) from the rabbit lung is relatively high in the newborn and increases rapidly after birth, attaining its maximum level at 15 days of age.
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