Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance.

  title={Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance.},
  author={Brian P. Vickery and Laurent Pons and Mike J. Kulis and Pamela N Steele and Stacie M. Jones and Arvil Wesley Burks},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  volume={105 6},
BACKGROUND Hen's egg allergy is among the most common food allergies in childhood and predicts later development of allergic disease. The optimal efficacy and mechanism(s) of egg allergen immunotherapy are poorly understood. OBJECTIVE To enhance immunologic and clinical outcomes of egg oral immunotherapy (OIT) using a conditionally increased dosing strategy. METHODS In an open-label clinical trial of egg OIT, egg-allergic children ingested daily doses of egg protein that were gradually… CONTINUE READING
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