Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing.

Abstract

OBJECTIVES (1) To quantify hydrocodone (HC) and hydromorphone (HM) metabolite pharmacokinetics with pharmacogenetics in CYP2D6 ultra-rapid metabolizer (UM), extensive metabolizer (EM), and poor metabolizer (PM) metabolizer phenotypes. (2) To develop an HC phenotype-specific dosing strategy for HC that accounts for HM production using clinical… (More)
DOI: 10.1097/AJP.0000000000000214

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Cite this paper

@article{Linares2015IndividualizedHT, title={Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing.}, author={Oscar A. C. Linares and Jeffrey Fudin and Annemarie L Daly and Raymond C. Boston}, journal={The Clinical journal of pain}, year={2015}, volume={31 12}, pages={1026-35} }