Individual-specific ‘fingerprints’ of human DNA

  title={Individual-specific ‘fingerprints’ of human DNA},
  author={Alec John Jeffreys and Victoria Wilson and Swee Lay Thein},
Simple tandem-repetitive regions of DNA (or ‘minisatellites’) which are dispersed in the human genome frequently show substantial length polymorphism arising from unequal exchanges which alter the number of short tandem repeats in a minisatellite1–4. We have shown previously that the repeat elements in a subset of human minisatellites share a common 10–15-base-pair (bp) ‘core’ sequence which might act as a recombination signal in the generation of these hypervariable regions5. A hybridization… 
Positive identification of an immigration test-case using human DNA fingerprints
The potential for positive or inclusive identification is illustrated and the DNA fingerprint analysis of an immigration case is described, the resolution of which would have been very difficult and laborious using currently available single-locus genetic markers.
DNA Fingerprints Applied to Individual Identification and Paternity Testing in Bovines
The individual identification and paternity testing of bovines using DNA fingerprints is attempted and it is suggested that human repeat-core probes might crosshybridize to animal minisatellite.
Characterization of a panel of highly variable minisatellites cloned from human DNA
Five of the most variable loci detected in human DNA by hybridization with DNA fingerprint probes have been cloned and characterized, and are illustrated by an analysis of forensic specimens from two victims who had been sexually assaulted and murdered.
Characterization of a VNTR sequence on human Chromosome 22 revealing polymorphic cross-hybridizing sequences in mammals
Hypervariable regions, also termed "minisatellites" or variable number of tandem repeats (VNTR), first discovered in the human genome (Wyman and White 1980), consist of a core tandem repeat sequence
DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees.
Tandem-repetitive DNA hybridization probes based on a putative human recombination signal detect multiple polymorphic minisatellite fragments in human DNA and can be applied to linkage analysis in human pedigrees.
Genome scanning by two‐dimensional DNA typing: The use of repetitive DNA sequences for rapid mapping of genetic traits
An electrophoretic system, two‐dimensional DNA typing, which may fulfill the requirements of fully exploring the various sets of mammalian repeat sequences and can greatly accellerate the mapping of genetic traits in humans, animals, and plants.
Detection of recombination in variable number tandem repeat sequences
The goal is to develop an adequate tool for the detection of recombinant among a set of minisatellite sequences by combining a multiple alignment tool and a method based on phylogenetic profiling, and a first solution, called MS PhylPro, is designed.
Forensic Use of Short Tandem Repeats via PCR
The DNA sequence of man’s chromosomes has the potential for wide variation from individual to individual since only 1% encodes functional elements, i.e. genes, and the large number of alleles provides a very powerful DNA-based personal identification method.


Hypervariable ‘minisatellite’ regions in human DNA
A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Molecular basis of length polymorphism in the human zeta-globin gene complex.
The homology between the three length polymorphisms may be an indication of the presence of a more widespread group of related sequences in the human genome, which might be useful for generalized linkage studies.
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences
The sequence of the highly polymorphic region near the human insulin gene, which begins 363 base pairs before the start of transcription and extends upstream, indicated that it is generated by
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least
Gel electrophoresis of restriction fragments.
The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV
Continuous human lymphoblastoid cell lines (LL), derived from lymphoid tissue or peripheral blood of 20 adults without histories of recent infectious mononucleosis at a frequency close to 100 %, were