Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein.

@article{Crane2013IndividualPI,
  title={Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein.},
  author={Courtney A. Crane and Seunggu J. Han and Brian J. Ahn and Jessica Oehlke and Valerie A Kivett and Anne Fedoroff and Nicholas A. Butowski and Susan M. Chang and Jennifer Lynn Clarke and Mitchel S. Berger and Michael W. Mcdermott and Michael D. Prados and Andrew T. Parsa},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 1},
  pages={205-14}
}
PURPOSE Cancer immunotherapy offers hope of a highly specific nontoxic adjuvant treatment. Heat shock protein peptide complexes (HSPPCs) found in cancer cells carry tumor-specific antigenic proteins and can facilitate adaptive and innate immune responses. Here we show that peptides bound to a 96 kD chaperone protein (HSP-96) from brain tissue containing… CONTINUE READING