Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

Abstract

PURPOSE Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium. MATERIALS… (More)
DOI: 10.1016/j.radonc.2016.06.017

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@article{Andreassen2016IndividualPD, title={Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.}, author={Christian Nicolaj Andreassen and B. Rosenstein and Sarah Kerns and Harry Ostrer and Dirk K. M. De Ruysscher and Jamie A. Cesaretti and Gillian C. Barnett and Alison M. Dunning and Leila Dorling and Catharine M. West and Neil G. Burnet and Rebecca Elliott and Charlotte H. Coles and Emma Hall and Laura Fachal and A. de la Vega and Antonio G{\'o}mez-Caama{\~n}o and Christopher J. Talbot and R. Paul Symonds and Kim De Ruyck and Hubert Thierens and Piet Ost and Jenny Chang-Claude and Petra Seibold and Odilia Popanda and Marie Overgaard and David Dearnaley and Matthew R. Sydes and David Azria and Christine Anne Koch and Matthew B. Parliament and Michael T. Blackshaw and Michael Sia and Mar{\'i}a J. Fuentes-Raspall and Teresa Ram{\'o}n Y Cajal and A Barnadas and Danny Vesprini and Sara Guti{\'e}rrez-Enr{\'i}quez and Meritxell Moll{\`a} and Orland D{\'i}ez and John R. Yarnold and Jens Overgaard and S\oren Bentzen and Jan Alsner}, journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology}, year={2016}, volume={121 3}, pages={431-439} }