Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?

@article{Nunemaker2005IndividualMC,
  title={Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?},
  author={Craig S Nunemaker and Min Zhang and David H. Wasserman and Owen P. McGuinness and Alvin C Powers and Richard Bertram and Arthur Sherman and Leslie S. Satin},
  journal={Diabetes},
  year={2005},
  volume={54 12},
  pages={3517-22}
}
Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic glucose-dependent intracellular calcium concentration ([Ca2+]i) pulsatility of individual islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca2+]i oscillations. We show that the period of islet [Ca2+]i oscillations is unique to each mouse, with the islets from an individual mouse demonstrating similar rhythms to one another. Based on their rhythmic period, mice were broadly… CONTINUE READING