Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects.

Abstract

Tensins are large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins. Tensins are multidomain proteins consisting of homologous C1, PTPase, C2, SH2 and PTB domains. Full-length Tensin proteins can undergo cleavage inside cells, thus yielding domains in isolation that may have discrete subcellular localisations… (More)
DOI: 10.1016/j.biocel.2009.09.005

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