Individual differences in vulnerability to drug abuse: the high responders/low responders model.

@article{Kabbaj2006IndividualDI,
  title={Individual differences in vulnerability to drug abuse: the high responders/low responders model.},
  author={Mohamed Kabbaj},
  journal={CNS & neurological disorders drug targets},
  year={2006},
  volume={5 5},
  pages={513-20}
}
  • Mohamed Kabbaj
  • Published 2006 in CNS & neurological disorders drug targets
In this review we shall attempt to summarize the literature published on the high responders/low responders' animal model of drug addiction. This model is based on the locomotor activity of rats in the mild stress of a novel environment. Rats that exhibit high rates of exploratory behaviours are deemed high responders (HR) and rats that exhibit low exploratory behaviours are deemed low responders (LR). Interestingly, the rate of these exploratory behaviours predicts the response of these… CONTINUE READING

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