Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study

@article{Modi2013IndividualDI,
  title={Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study},
  author={Shilpi Modi and Richa Trivedi and Kavita Singh and Pawan Kumar and Ram Kishore Singh Rathore and Rajendra Prashad Tripathi and Subash Khushu},
  journal={Behavioural Brain Research},
  year={2013},
  volume={238},
  pages={188-192}
}
Trait anxiety, a personality dimension that measures an individual's higher disposition to anxiety, has been found to be associated with many functional consequences viz. increased distractibility, attentional bias in favor of threat-related information etc. Similarly, volumetric studies have reported morphological changes viz. a decrease in the volume of left uncinate fasciculus (fiber connecting anterior temporal areas including the amygdala with prefrontal-/orbitofrontal cortices) and an… 
White Matter-Based Structural Brain Network of Anxiety.
TLDR
Studies of white matter status in anxiety revealed overlapping patterns of front-cortical and fronto-limbic changes with uncinate fasciculus and cingulum alterations a frequent component.
Cerebral White Matter Changes in Young Healthy Individuals With High Trait Anxiety: A Tract-Based Spatial Statistics Study
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Non-clinical individuals with high anxiety already have white matter alterations in the thalamus-cortical circuit and some emotion-related areas that were widely reported in anxiety-related disorders, which can deepen the understanding of the pathological mechanism of anxiety and further support the need for preventive interventions in high anxiety individuals.
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The results suggest that the microstructural features of the uncinate fasciculus, and these other association white matter fibers, may support emotion regulatory processes with greater white matter integrity facilitating healthier affective functioning.
The Inverse Relationship between the Microstructural Variability of Amygdala-Prefrontal Pathways and Trait Anxiety Is Moderated by Sex
TLDR
A moderating effect of sex was found, demonstrating that the observed brain-anxiety relationship was stronger in females, and data reveal a potential neuroanatomical mediator of previously documented functional alterations in amygdala-prefrontal connectivity that is associated with trait anxiety.
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TLDR
This study demonstrated the feasibility and advantages of adopting the MZ twin design for DTI measures in neuroimaging research and examined the relationship between structural characteristics of the uncinate fasciculus measured by Diffusion Tensor Imaging and anxiety symptoms in a sample of monozygotic, adolescent twins.
Emotion Regulation and Trait Anxiety Are Predicted by the Microstructure of Fibers between Amygdala and Prefrontal Cortex
TLDR
Investigation of white matter differences in persons featuring an anxious or a nonanxious personality, taking into account all potential pathway connections between amygdala and anxiety-related regions of the prefrontal cortex, revealed that trait anxiety predicts the microstructural properties of a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex.
Glutamate level in anterior cingulate predicts anxiety in healthy humans: A magnetic resonance spectroscopy study
TLDR
The study provides a first account of alterations in anterior cingulate cortex neurochemistry in relation to anxiety in healthy subjects and contributes to the limited literature available on altered metabolism and neural mechanisms underlying sub-clinical anxiety.
Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
TLDR
The CD + AD and AD groups showed similarly reduced structural integrity of the left uncinate compared to ND, even after adjusting for IQ, psychiatric comorbidity, and childhood maltreatment.
Neuroticism is linked to microstructural left-right asymmetry of fronto-limbic fibre tracts in adolescents with opposite effects in boys and girls
TLDR
The findings suggest that the link between neuroticism and frontal‐limbic white matter microstructure asymmetry likely predates early adolescence, and sex differences in the neural correlates of neuroticism are observed.
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References

SHOWING 1-10 OF 34 REFERENCES
Volumetric associations between uncinate fasciculus, amygdala, and trait anxiety
TLDR
The present study emphasizes the role of the left UF as candidate WM fiber bundle associated with anxiety-related processes and suggests that fiber bundle volume is a WM measure of particular interest and substantiates the structural relatedness of UF and amygdala by a non-invasive imaging method.
Individual differences in trait anxiety are associated with white matter tract integrity in the left temporal lobe in healthy males but not females
TLDR
Self-report data of personality dimensions linked to trait anxiety in the context of white matter tract integrity in the temporal lobes of the human brain are investigated in a large sample of N=110 healthy participants.
Linking an anxiety-related personality trait to brain white matter microstructure: diffusion tensor imaging and harm avoidance.
TLDR
Testing the hypothesis that individuals with high scores on the harm avoidance (HA) subscale of the Temperament and Character Inventory show reduced white matter (WM) structural integrity in distributed brain areas, including corticolimbic pathways involved in emotional processing and reappraisal concluded that structural connectivity modulates anxiety-related aspects of personality.
Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder.
TLDR
The study results provide further evidence for OCD-related white matter abnormalities in the ALIC and cingulum, consistent with a cortico striatal model of OCD.
White matter alterations in social anxiety disorder.
TLDR
Previous results pointing to frontal WM alterations in or near the UF in patients with SAD are partially confirmed, and SAD-specific dimensional associations of FA with trait anxiety might reflect general pathological and/or compensate mechanisms as a function of symptom severity in patients.
Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits.
TLDR
It is suggested that smaller right hippocampal volume underlies the basis for higher anxiety-related traits common to both genders, whereas anterior prefrontal volume contributes only in females.
The Structural Integrity of an Amygdala–Prefrontal Pathway Predicts Trait Anxiety
TLDR
This study illustrates a strategy for combining fMRI and DTI to identify individual differences in structural pathways that predict behavioral outcomes and shows that the strength of an axonal pathway identified between the amygdala and prefrontal cortex predictedindividual differences in trait anxiety.
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
TLDR
The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fascicule suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia.
Altered fimbria-fornix white matter integrity in anorexia nervosa predicts harm avoidance
TLDR
The prediction of Harm Avoidance in AN by fimbria-fornix WM integrity suggests that this pathway may be mechanistically involved in high anxiety in AN, which could contribute to disturbed feeding, emotion processing and body perception in AN.
Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder
TLDR
These findings suggest that MDD may be associated with abnormal microstructure in brain reward/aversion regions, and that there may be at least two subtypes of microstructural abnormalities which each impact core symptoms of depression.
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