Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study

@article{Modi2013IndividualDI,
  title={Individual differences in trait anxiety are associated with white matter tract integrity in fornix and uncinate fasciculus: Preliminary evidence from a DTI based tractography study},
  author={Shilpi Modi and Richa Trivedi and Kavita Singh and Pawan Kumar and Ram Kishore Singh Rathore and Rajendra Prashad Tripathi and Subash Khushu},
  journal={Behavioural Brain Research},
  year={2013},
  volume={238},
  pages={188-192}
}
White Matter-Based Structural Brain Network of Anxiety.
TLDR
Studies of white matter status in anxiety revealed overlapping patterns of front-cortical and fronto-limbic changes with uncinate fasciculus and cingulum alterations a frequent component.
Cerebral White Matter Changes in Young Healthy Individuals With High Trait Anxiety: A Tract-Based Spatial Statistics Study
TLDR
Non-clinical individuals with high anxiety already have white matter alterations in the thalamus-cortical circuit and some emotion-related areas that were widely reported in anxiety-related disorders, which can deepen the understanding of the pathological mechanism of anxiety and further support the need for preventive interventions in high anxiety individuals.
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TLDR
The results suggest that the microstructural features of the uncinate fasciculus, and these other association white matter fibers, may support emotion regulatory processes with greater white matter integrity facilitating healthier affective functioning.
The Inverse Relationship between the Microstructural Variability of Amygdala-Prefrontal Pathways and Trait Anxiety Is Moderated by Sex
TLDR
A moderating effect of sex was found, demonstrating that the observed brain-anxiety relationship was stronger in females, and data reveal a potential neuroanatomical mediator of previously documented functional alterations in amygdala-prefrontal connectivity that is associated with trait anxiety.
Age-related reduced prefrontal-amygdala structural connectivity is associated with lower trait anxiety.
TLDR
These findings argue against the notion that greater amygdala-vPFC structural integrity facilitates better anxiety outcomes in healthy adults and suggest that white matter degeneration in this network relates to lower anxiety in older adults.
Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
TLDR
This study demonstrated the feasibility and advantages of adopting the MZ twin design for DTI measures in neuroimaging research and examined the relationship between structural characteristics of the uncinate fasciculus measured by Diffusion Tensor Imaging and anxiety symptoms in a sample of monozygotic, adolescent twins.
Emotion Regulation and Trait Anxiety Are Predicted by the Microstructure of Fibers between Amygdala and Prefrontal Cortex
TLDR
Investigation of white matter differences in persons featuring an anxious or a nonanxious personality, taking into account all potential pathway connections between amygdala and anxiety-related regions of the prefrontal cortex, revealed that trait anxiety predicts the microstructural properties of a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex.
Glutamate level in anterior cingulate predicts anxiety in healthy humans: A magnetic resonance spectroscopy study
Amygdala-orbitofrontal structural and functional connectivity in females with anxiety disorders, with and without a history of conduct disorder
TLDR
The CD + AD and AD groups showed similarly reduced structural integrity of the left uncinate compared to ND, even after adjusting for IQ, psychiatric comorbidity, and childhood maltreatment.
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