Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1.

@article{Bleiber2001IndividualCO,
  title={Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1.},
  author={Gabriela Bleiber and M. L. Mu{\~n}oz and Angela Ciuffi and Pascal R. A. Meylan and Amalio Telenti},
  journal={Journal of virology},
  year={2001},
  volume={75 7},
  pages={3291-300}
}
Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease (PR) and reverse transcriptase (RT) inhibitors may display impaired infectivity and replication capacity. The individual contributions of mutated HIV-1 PR and RT to infectivity, replication, RT activity, and protein maturation (herein referred to as "fitness") in recombinant viruses were investigated by separately cloning PR, RT, and PR-RT cassettes from drug-resistant mutant viral isolates into the wild-type NL4-3… CONTINUE READING
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