Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors.

@article{Driessen2001IndividualCD,
  title={Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors.},
  author={Christoph Driessen and Ana Mar{\'i}a Lennon-Dum{\'e}nil and Hidde L. Ploegh},
  journal={European journal of immunology},
  year={2001},
  volume={31 5},
  pages={1592-601}
}
We have analyzed the intracellular degradation of an immune complex after its FcgammaR-mediated uptake in antigen-presenting cells (APC). Mice that lack the cathepsins (Cat) S, L, B and D allowed us to assess the direct contribution of these individual proteases to the processing events observed. CatS and CatB mediate the bulk of degradation of the Ig-125I-labeled F(ab')2 immune complex delivered via FcgammaR, while CatL and CatD are dispensable. CatS and CatB are involved in independent… CONTINUE READING

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