Individual Sensitivity to Genotoxic Effects of Nickel and Antimutagenic Activity of Ascorbic Acid

@article{Perminova2001IndividualST,
  title={Individual Sensitivity to Genotoxic Effects of Nickel and Antimutagenic Activity of Ascorbic Acid},
  author={I. N. Perminova and T. A. Sinel'shchikova and N. I. Alekhina and Elena V Perminova and G. D. Zasukhina},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2001},
  volume={131},
  pages={367-370}
}
Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals. 

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