Individual Patterns of Dynamic QT/RR Relationship in Survivors of Acute Myocardial Infarction and Their Relationship to Antiarrhythmic Efficacy of Amiodarone

@article{Smetana2004IndividualPO,
  title={Individual Patterns of Dynamic QT/RR Relationship in Survivors of Acute Myocardial Infarction and Their Relationship to Antiarrhythmic Efficacy of Amiodarone},
  author={Peter Smetana and Esther Pueyo and Katerina Hnatkova and Velislav N. Batchvarov and Pablo Laguna and Marek Malik},
  journal={Journal of Cardiovascular Electrophysiology},
  year={2004},
  volume={15}
}
INTRODUCTION Amiodarone is an effective antiarrhythmic drug, but it has serious side effects and conducted trials did not support its prophylactic use in survivors of acute myocardial infarction. [] Key Method A commercial Holter system was used to measure RR and QT intervals. Subject-specific descriptors of QT/RR relationship were calculated. Comparison was performed in amiodarone- and placebo-treated patients, distinguishing patients who did and did not suffer from arrhythmic death. QT/RR relationship and…
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Can We Predict Antiarrhythmic Efficacy or Inefficacy of Amiodarone or Any Other Antiarrhythmic? What This Patient Needs Is a Doctor!
  • G. Naccarelli
  • Medicine, Biology
    Journal of cardiovascular electrophysiology
  • 2004
TLDR
The novel finding that changes in the QT/RR relationship can be used to predict the efficacy of amiodarone for a high-risk postmyocardial infarction from the EMIAT trial was reported and reduced optimum regression residuum and flatter slope of theQT/ RR relationship independently predicted arrhythmic death during followup.
QT/RR Relationship in Patients after Remote Anterior Myocardial Infarction with Left Ventricular Dysfunction and Different Types of Ventricular Arrhythmias
  • K. Szydło, M. Trusz‐Gluza, +6 authors Z. Tabor
  • Medicine
    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
  • 2008
TLDR
Differences in QT/RR relationship in patients after remote anterior MI with left ventricular dysfunction and different types of ventricular arrhythmias are calculated.
QT as a predictor of recurrence after atrial fibrillation ablation and the impact of amiodarone: results from the placebo-controlled AMIO-CAT trial.
  • S. Diederichsen, S. Darkner, +4 authors J. Svendsen
  • Medicine, Biology
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2019
TLDR
Prolonged corrected QT interval at baseline independently predicted AF/AT recurrence, and baseline QTc identified patients who would possibly benefit from short-term amiodarone following ablation.
Drug-induced QT prolongation and proarrhythmia: an inevitable link?
  • K. Ahmad, P. Dorian
  • Medicine
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2007
TLDR
The presumed relationship between the QT interval and myocardial repolarization will be deconstructed, demonstrating that most of the important aspects ofRepolarization, and subsequent arrhythmogenesis, cannot be understood only through the simple numerical measurement of theQT interval.
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Based on experimental studies, heterogeneous ventricular repolarization has been suggested to predispose to the onset of life-threatening ventricular arrhythmias and subsequent studies in various…
Effects of antiarrhythmics and hypokalemia on the rate adaptation of cardiac repolarization
  • O. Osadchii
  • Biology, Medicine
    Scandinavian cardiovascular journal : SCJ
  • 2018
TLDR
The rate adaptation of ventricular repolarization is delayed by arrhythmogenic interventions, such as quinidine, procainamide, and hypokalemia, but not changed by lidocaine, a clinically safe antiarrhythmic agent.
Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk.
TLDR
It is suggested that protracted QTI adaptation could be an indicator of altered [Na(+)](i) dynamics following Na(+)/K(+) pump inhibition as it occurs in patients with ischemia or heart failure.
Neuromodulation of Cardiac Repolarization and Arrhythmogenesis
TLDR
Increasing evidence shows that non-pharmacologic modulation of the ANS that has initially been underutilized is now one of the main therapeutic strategies in the treatment of cardiac arrhythmias.
Isoprenaline increases Excursive Restitution Slope in the Conscious Rabbit with Ischaemic Heart Failure
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Ischaemic heart failure produces steeper restitution slopes during beta-adrenergically induced QT/TQ hysteresis, which could underlie the propensity of failing hearts to arrhythmias.
Differences in the Slope of the QT-RR Relation Based on 24-Hour Holter ECG Recordings between Cardioembolic and Atherosclerotic Stroke
TLDR
The increased slope of the QT-RR linear regression line based on 24-hour Holter ECG in patients with ischemic stroke presenting in sinus rhythm may be a simple and useful marker for cardioembolic stroke.
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