Indium-catalyzed reductive alkylation of pyrroles with alkynes and hydrosilanes: selective synthesis of beta-alkylpyrroles.


Mixing readily available alkynes, pyrroles, and triethylsilane along with an indium catalyst was found to be an efficient procedure to introduce alkyl groups onto a beta-position of pyrroles in a complete regioselective manner. This is the first demonstration of catalytic beta-alkylation of pyrroles in a single step. 
DOI: 10.1021/ol900651u