Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers.

@article{Redondo1992IndistinguishableNF,
  title={Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers.},
  author={Juan Miguel Redondo and Jeffrey L. Pfohl and Cristina Hern{\'a}ndez-Munain and Shuli Wang and Nancy A Speck and Michael S Krangel},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 11},
  pages={
          4817-23
        }
}
We have previously shown that the delta E3 site is an essential element for transcriptional activation by the human T-cell receptor (TCR) delta enhancer and identified two factors, NF-delta E3A and NF-delta E3C, that bound to overlapping core (TGTGGTTT) and E-box motifs within delta E3. In this study, we show that protein binding to the core motif is necessary but not sufficient for transcriptional activation by the delta E3 element. In contrast, protein binding to the E-box motif does not… CONTINUE READING

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