Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation.

@article{Inokuma2006IndispensableRO,
  title={Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation.},
  author={Ken-ichi Inokuma and Yuko Okamatsu-Ogura and Asako Omachi and Yukiko Matsushita and Kazuhiro Kimura and Hitoshi Yamashita and Masayuki Saito},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={290 5},
  pages={
          E1014-21
        }
}
Mitochondrial uncoupling protein-1 (UCP1) has been thought to be a key molecule for thermogenesis during cold exposure and spontaneous hyperphagia and thereby in the autonomic regulation of energy expenditure and adiposity. However, UCP1 knockout (KO) mice were reported to be cold intolerant but unexpectedly did not get obese even after hyperphagia, implying that UCP1 may not be involved in the regulation of adiposity. Treatment of obese animals with beta3-adrenergic agonists is known to… CONTINUE READING

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