Indispensable role of Mdm2/p53 interaction during the embryonic and postnatal inner ear development

@inproceedings{Laos2017IndispensableRO,
  title={Indispensable role of Mdm2/p53 interaction during the embryonic and postnatal inner ear development},
  author={Maarja Laos and Marilin Sulg and Anni Herranen and Tommi Anttonen and Ulla Pirvola},
  booktitle={Scientific reports},
  year={2017}
}
p53 is a key component of a signaling network that protects cells against various stresses. As excess p53 is detrimental to cells, its levels are tightly controlled by several mechanisms. The E3 ubiquitin ligase Mdm2 is a major negative regulator of p53. The significance of balanced p53 levels in normal tissues, at different stages of lifetime, is poorly… CONTINUE READING