Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.

@article{Sethi2006IndirubinET,
  title={Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.},
  author={Gautam Sethi and Kwang Seok Ahn and Santosh Kumar Sandur and Xin Lin and Madan Mohan Chaturvedi and Bharat Bhushan Aggarwal},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 33},
  pages={
          23425-35
        }
}
Although indirubin is known to exhibit anti-cancer and anti-inflammatory activities, very little is known about its mechanism of action. In this study, we investigated whether indirubin mediates its effects through interference with the NF-kappaB pathway. As examined by the DNA binding of NF-kappaB, we found that indirubin suppressed tumor necrosis factor (TNF)-induced NF-kappaB activation in a dose- and time-dependent manner. Indirubin also suppressed the NF-kappaB activation induced by… CONTINUE READING
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Indirubin Enhances Tumor Necrosis Factor-induced Apoptosis through Modulation of Nuclear Fact.

Z. L. Chu, T. A. McKinsey, +3 authors D. Ballard
Proc. Natl. Acad. Sci. U. S. A • 1997
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