Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.

@article{Nam2005IndirubinDI,
  title={Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.},
  author={Sangkil Nam and Ralf Buettner and James Turkson and Donghwa Kim and Jin Quan Cheng and Stephan Muehlbeyer and Frankie Hippe and Sandra Vatter and Karl-Heinz Merz and Gerhard Eisenbrand and Richard Jove},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 17},
  pages={5998-6003}
}
Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle arrest. Here, we show that the indirubin derivatives E564, E728, and E804 potently block constitutive Stat3… CONTINUE READING