Indirubin-3′-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK

@article{Zhen2007Indirubin3monoximeIA,
  title={Indirubin-3′-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK},
  author={Yuanhuan Zhen and Vigdis S\orensen and Yi Jin and Zhimin Suo and Antoni Więdłocha},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6372-6385}
}
Indirubin-3′-monoxime is a derivative of the bis-indole alkaloid indirubin, an active ingredient of a traditional Chinese medical preparation that exhibits anti-inflammatory and anti-leukemic activities. Indirubin-3′-monoxime is mainly recognized as an inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3. It inhibits proliferation of cultured cells, mainly through arresting the cells in the G1/S or G2/M phase of the cell cycle. Here, we report that indirubin-3′-monoxime… CONTINUE READING

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